膜科学与技术

中空纤维膜渗透性对透析器内滤过性能的影响

作者：牟倡骏，王禹峰，张洁敏，王磊，许洁，江君杰

单位：山东威高血液净化制品股份有限公司研发部，威海264210

关键词：血液透析；渗透性；内滤过

出版年,卷(期):页码： 2023,43(1):127-132

摘要：

探究了在血液净化领域中，中空纤维膜渗透性对透析器内滤过、尿毒症毒素清除率性能的影响，并进行白蛋白筛选测试。结果表明，膜渗透性的增强有效增加内滤过流量，增强血液透析时对流传质效应。该效应对小分子溶质清除率影响较小，但对中大分子溶质明显提升。本实验中，当膜渗透性增加至最大时，溶质清除率达到最佳，同时其白蛋白筛选符合临床要求。本研究有助于高性能透析器的研发，从而提升透析患者的治疗效果。

Abstract: In this paper, in the field of blood purification, the effect of hollow fiber membrane with different permeabilities on the internal filtration and clearance of uremic toxins was investigated in the dialyzers, and the albumin sieving coefficient was tested. The results showed that the enhanced membrane permeability effectively improved the internal filtration of the dialyzers and thus increased the effect of convective transport during hemodialysis, which means that the ability of the dialyzers to remove medium and large molecular weight solutes was obviously improved. In this experiment, when the membrane permeability reached the maximum, the solute removal ability of the dialyzers was the best, and the albumin sieving coefficient met the clinical requirements. This research contributes to the development of high-performance dialyzers to improve treatment effects for patients with kidney disease.

牟倡骏(1982-),男，山东威海人，高级工程师，博士研究所，从事血液净化类全线耗材及设备类产品开发

参考文献：

服务与反馈：

【文章下载】【加入收藏】

《膜科学与技术》编辑部地址：北京市朝阳区北三环东路19号蓝星大厦邮政编码：100029 电话：010-64426130/64433466 传真：010-80485372邮箱：mkxyjs@163.com